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In drug-induced pyridoxine deficiency, such as in patients taking isoniazid, a higher replacement dose is often used, for example, 100 mg IV or IM daily for 3 weeks, to rapidly correct the deficiency, followed by a maintenance dose of around 30 mg daily

Breastfeeding mothers are both recovering from their pregnancy and delivery and producing milk for their newborn two incredibly demanding physiological processes

Choi et al., 2020)

Research suggests that oral doses of up to 500 mg daily may be safe for short-term use (up to two months) without significant side effects

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Effect of leucovorin treatment on change in global developmental age (DA)